ISO/NP 24934

Genomics informatics — Multi-Omics Quality Control and Data Integration

Scope

This document specifies the quality control metrics and procedures for multi-omics profiles and data integration to achieve reproducibility in multi-omics studies. Multi-omics encompasses, but is not limited to, genomics, epigenomics, transcriptomics, proteomics, and metabolomics. The purposes of multi-omics studies may include the classification of samples and the identification of differentially expressed omics features.
This document is applicable to assessing the quality of normalized multi-omics profiles with both qualitative and quantitative data values. The quality control metrics described are intended for assessing the aggregated normalized data. This document assumes that the quality of normalized profiles reflects the overall proficiency of a laboratory or the quality of a multi-omics study.
This document is not intended for
— The experimental processes involved in obtaining raw data from samples.
— The analytical processes involved in transforming raw data or intermediate data into normalized profiles.