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ISO 23921:2020

Cigarettes — Determination of tobacco specific nitrosamines in mainstream cigarette smoke with an intense smoking regime — Method using LC-MS/MS

Publication date:   Sep 30, 2020

General information

90.60   Close of review   Dec 3, 2025

ISO

ISO/TC 126 Tobacco and tobacco products

International Standard

65.160   Tobacco, tobacco products and related equipment

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Scope

This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in the total particulate matter of cigarette mainstream smoke with the intense smoking regime specified in ISO 20778 by using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS). The quantified TSNAs are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

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PUBLISHED
ISO 23921:2020
90.60 Close of review
Dec 3, 2025