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ISO 21427-2:2006

Water quality — Evaluation of genotoxicity by measurement of the induction of micronuclei — Part 2: Mixed population method using the cell line V79

Publication date:   Nov 8, 2006

General information

90.60   Close of review   Jun 5, 2026

ISO

ISO/TC 147/SC 5 Biological methods

International Standard

13.060.70   Examination of biological properties of water

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Scope

ISO 21427-2:2006 specifies a method for the determination of genotoxicity of water and waste water using a mammalian in vitro test which detects damage, induced by water-soluble substances, to the chromosomes or the mitotic apparatus of V79 cells from the Chinese hamster.
The micronucleus test allows the identification of substances that cause cytogenetic damage which results in the formation of micronuclei containing lagging chromosome fragments and/or whole chromosomes.
The assay is based on the increase in the frequency of micronucleated cells after incubation with and without metabolic activation.

Life cycle

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PUBLISHED
ISO 21427-2:2006
90.60 Close of review
Jun 5, 2026

CORRIGENDA / AMENDMENTS

PUBLISHED
ISO 21427-2:2006/Cor 1:2009